The Chang-Moore Laboratory in the Cancer Virology Program at the University of Pittsburgh Cancer Institute is responsible for discovering the viral causes of four different human cancers. In 1994, Chang-Moore lab identified and isolated Kaposi’s sarcoma-associated herpesvirus (KSHV) causing this epidemic cancer among HIV/AIDS patients (listen to a description of KSHV discovery). In addition to KS, KSHV causes primary effusion lymphoma (PEL) and most cases of multi centric Castleman’s disease (MCD). The Chang-Moore lab also developed a new technology (digital transcriptome subtraction, or DTS) for identifying human cancer viruses and in 2008 discovered Merkel cell polyomavirus (MCV) causing most Merkel cell carcinomas. Drs. Moore and Chang are a husband and wife research team.
Research in the Chang-Moore laboratory ranges from basic biological investigations into how cells become cancerous to epidemiologic/clinical research into the diagnosis, treatment and prevention of cancers caused by viruses.