We are working hard to make new discoveries about Merkel Cell Polyomavirus. If you or someone you love has been diagnosed with MCC, check out our page for patients and friends for resources and information.





Yuan Chang and Pat Moore receive the 2017 Paul Ehrlich Prize.


KSHV LANA generates novel cytoplasmic proteins through non canonical translation initiation J Virol. 2012 Dec 19


Dr. Chang presents the Provost's Inaugural Lecture

Dr. Yuan Chang Presenting the Provost’s Inaugural Lecture “Merkel Cell Polyomavirus: Discovery and Implications


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New NIH Funding

Welcome to the Chang-Moore Lab Homepage

Welcome to the home page of Dr. Yuan Chang and
Dr. Patrick Moore’s laboratory.

The Chang-Moore Laboratory in the Cancer Virology Program at the University of Pittsburgh Cancer Institute is responsible for discovering the viral causes of four different human cancers. In 1994, Chang-Moore lab identified and isolated Kaposi’s sarcoma-associated herpesvirus (KSHV) causing this epidemic cancer among HIV/AIDS patients (listen to a description of KSHV discovery). In addition to KS, KSHV causes primary effusion lymphoma (PEL) and most cases of multicentric Castleman’s disease (MCD). The Chang-Moore lab also developed a new technology (digital transcriptome subtraction, or DTS) for identifying human cancer viruses and in 2008 discovered Merkel cell polyomavirus (MCV) causing most Merkel cell carcinomas. Drs. Moore and Chang are a husband and wife research team.

Research in the Chang-Moore laboratory ranges from basic biological investigations into how cells become cancerous to epidemiologic/clinical research into the diagnosis, treatment and prevention of cancers caused by viruses.

Here is a video introduction to our research. To know more, please visit the KSHV and MCV pages and feel free to contact us for more information.

August 16, 2015 Lab Personnel