The Chang-Moore Laboratory in the Cancer Virology Program at the University of Pittsburgh Cancer Institute is responsible for discovering the viral causes of four different human cancers. In 1994, Chang-Moore lab identified and isolated Kaposi’s sarcoma-associated herpesvirus (KSHV) causing this epidemic cancer among HIV/AIDS patients (listen to a description of KSHV discovery). In addition to KS, KSHV causes primary effusion lymphoma (PEL) and most cases of multi centric Castleman’s disease (MCD). The Chang-Moore lab also developed a new technology (digital transcriptome subtraction, or DTS) for identifying human cancer viruses and in 2008 discovered Merkel cell polyomavirus (MCV) causing most Merkel cell carcinomas. Drs. Moore and Chang are a husband and wife research team.
Research in the Chang-Moore laboratory ranges from basic biological investigations into how cells become cancerous to epidemiologic/clinical research into the diagnosis, treatment and prevention of cancers caused by viruses.
Top from Left: Nancy Davidson, Patrick Moore, Yuan Chang, Alison McBride, Cliona Rooney Bottom from Left: Dr. Chen, Herbert Virgin IV, Robert Yarchoan, Matthew Weitzman, Eric Engels The UPCI 30th Anniversary Symposia Series invited renow...Read More
The National Cancer Institute's R35 Outstanding Investigator Award is granted to researchers who have outstanding records of productivity in cancer research and who plan to continue or embark upon new projects of unusual potential in cancer...Read More
One of the most prestigious awards in the field of medicine will be presented to University of Pittsburgh School of Medicine faculty members Yuan Chang and Patrick S. Moore. Link. The award is given by the Paul Ehrlich Foundation. The m...Read More