Large T and small T antigens of Merkel cell polyomavirus

Abstract Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific mutations to the viral genome. Research on MCV large T (LT) and small T … Continue reading Large T and small T antigens of Merkel cell polyomavirus