All Publications

Chang-Moore Publications

2017

Kwun HJ*, Wendzicki JA*, Moore PS, Chang Y. Merkel Cell Polyomavirus small T Antigen Induces Genome Instability by E3 Ubiquitin Ligase Targeting. Oncogene. 2017. In Press.

Kwun HJ, Chang Y, Moore PS. Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Proc Natl Acad Sci USA. 2017. May 16;114(20):E4040-E4047. doi: 10.1073/pnas.1703879114. Epub 2017 May 1. [Full Text] | [PubMed]

Moore PS, Chang Y (2017) Common Commensal Cancer Viruses. PLoS Pathog 13(1): e1006078. https://doi.org/10.1371/journal.ppat.1006078 [Full Text]|[PubMed]

2016

T. Toptan, L. Rigatti, J. Newsome, P.S. Moore, and Y. Chang. Rat Polyomavirus 2 (RatPyV2): Identification and Characterization of a Novel Polyomavirus in a Colony of X-SCID Rats. mSphere00334-16R1. 2016.  [Full Text]|[PubMed]

Velasquez C, Cheng E, Shuda M, Lee-Oesterreich PJ, Pogge von Strandmann L, Gritsenko MA, Jacobs JM, Moore PS, Chang Y. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8466-71. doi: 10.1073/pnas.1607768113. Epub 2016 Jul 11. [Full Text]|[Link]

Toptan T., Yousem S.A., Ho J., Matsushima Y., Stabile LP, Fernandez-Figueras M-T, Bhargava R, Ryo A, Moore PS, Chang Y. Survey for human polyomaviruses in cancer. JCI Insight. 2016;1(2):e85562. doi:10.1172/jci.insight.85562. [Full Text]|[Link]

2015

Shuda M, Guastafierro A, Geng X, Shuda Y, Ostrowski SM, Lukianov S, Jenkins FJ, Honda K, Maricich SM, Moore PS, Chang Y. Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. PLoS One 2015 Nov 6;10(11):e0142329. [Full Text]|[Link]

Richards K, Guastafierro A, Shuda M, Toptan T, Moore PS, Chang Y. Merkel Cell Polyomavirus T Antigens Promote Cell Proliferation and Inflammatory Cytokine Gene Expression. J Gen Virol. 2015 Sep 17. doi: 10.1099/jgv.0.000287. [Full Text]|[Link]

Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav  D, Fasanella KE, Proskell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y. Human Polyomavirus 7-associated Pruritic Rash and Viremia in Transplant Recipients. J Infect Dis. 2015 May 15;211(10):1560-5. [Full Text]|[Link]

Shuda M, Velasquez C, Cheng E, Cordek DG, Kwun HJ, Chang Y, Moore PS. CDK1 substitutes for mTOR Kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 Apr 16. pii: 201505787. [Full Text]|[Link]

Wendzicki JA, Moore PS, Chang Y. Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol. 2015 Feb 11;11C:38-43. doi: 10.1016/j.coviro.2015.01.009. [Full Text]|[Link]

Kwun HJ, Shuda M, Camacho CJ, Gamper AM, Thant M, Chang Y, Moore PS. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J Virol. 2015 Apr 15;89(8):4191-200. doi: 10.1128/JVI.00157-15.[Full Text]|[Link]

2014

Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y. Human DNA Tumor Viruses Generate Alternative Reading Frame Proteins Through Repeat Sequence Coding. Proc Nat Acad Sci USA2014. [Full Text] |[PubMed]

Shuda M, Chang Y, Moore PS. Merkel Cell Polyomavirus Positive Merkel Cell Carcinoma Requires Viral Small T Antigen for Cell Proliferation. J Invest Dermatol2014 May;134(5):1479-81. [Full Text]|[PubMed]

Chang Y, Moore P. Twenty years of KSHV. Viruses. 2014 Nov 7;6(11):4258-64. doi: 10.3390/v6114258. [Full Text]|[Pubmed]

Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proskell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y. Human Polyomavirus 7-associated Pruritic Rash and Viremia in Transplant Recipients. J Infect Dis. 2014. [Full Text] |[PubMed]

Lachmann J1, Glaubke E1, Moore PS2, Ungermann C1. The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET. Cell Logist. 2014 Oct 2;4(4):e970840. [Full Text]| [PubMed]

Toptan T., Moore P.S., Chang Y. Kaposi’s Sarcoma-Associated Herpesvirus: General Features. Reference Module in Biomedical Sciences. 2014.

2013

Dresang LR, Guastafierro A, Arora R, Normolle D, Chang Y, Moore PS. Response of Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Xenografts to a Survivin Inhibitor. PLoS ONE. 2013 Nov 18;8(11):e80543. doi: 10.1371/journal.pone.0080543. eCollection 2013. [Full Text] ||[PubMed]

Shahzad N, Shuda M, Gheit T, Kwun HJ, Cornet I, Saidj D, Zannetti C, Hasan U, Chang Y, Moore PS, Accardi R, Tommasino M. The T Antigen locus of Merkel Cell Polyomavirus Down-regulates Human Toll-like Receptor 9 Expression. J Virol. 2013; 87(23):13009-19. [Full Text]|[PubMed]

Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y. Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7. Cell Host and Microbe2013; 14(2):125-135. [Full Text]|[PubMed]

Shuda M, Feng H, Moore PS, Chang Y. Merkel Cell Polyomavirus and Non-Small Cell Lung Cancer. Br J Cancer. 2013; 123(6):2964-702. [Full Text]|[PubMed]

Renwick N, Cekan P, Masry PA, McGeary SE, Miller JB, Hafner M, Li Z, Mihailovic  A, Morozov P, Brown M, Gogakos T, Mobin MB, Snorrason EL, Feilotter HE, Zhang X, Perlis CS, Wu H, Suarez-Farinas M, Feng H, Shuda M, Moore PS, Tron VA, Chang Y, Tuschl T. Multicolor microRNA fish effectively differentiates tumor types. J Clin Invest 2013; Jun 3;123(6):2694-702. [Full Text]|[PubMed]

Toptan T, Fonseca L, Kwun HJ, Chang Y, Moore PS. Complex Alternative Cytoplasmic Protein Isoforms of the Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Generated through Noncanonical Translation Initiation. J Virol. 2013 Mar. [Full Text]|[PubMed]

Forero A1, Moore PS, Sarkar SN. Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells. J Immunol. 2013 Aug 1;191(3):1476-85. doi: 10.4049/jimmunol.1202514. Epub 2013 Jun 26. [Full Text]|[PubMed]

2012

Guastafierro A, Feng H, Thant M, Kirkwood JM, Chang Y, Moore PS, Shuda M. Characterization of an early passage Merkel cell Polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods 2012;187(1):6-14. [Full Text]|[PubMed]

Arora R, Shuda M, Guastafierro A, Feng H, Toptan T, Tolstov Y, Normolle D, Vollmer LL, Vogt A, Damling A, Brodsky JL, Chang Y, Moore PS. Survivin is a therapeutic target in merkel cell carcinoma. Sci Transl Med. 2012 May 9;4(133):133ra56. [Full Text]|[PubMed]

Li Z, Ender C, Meister G, Moore PS, Chang Y, John B. Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res. 2012 Apr 9. [Full Text]|[PubMed]

Akgül B, Zigrino P, Hufbauer M, Liu X, Moore PS, Mauch C, Pfister H. Lack of integrin 5 in Merkel cell carcinomas and derived cell lines is frequently associated with Merkel cell polyomavirus. J Dermatol Sci. 2012 Jul;67(1):66-8. doi: 10.1016/j.jdermsci.2012.03.006. Epub 2012 Mar 30. [Full Text]|[PubMed]

Arora R, Chang Y, Moore PS. MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol. 2012 Aug;2(4):489-98. doi: 10.1016/j.coviro.2012.05.007. Epub 2012 Jun 17.2012 Jun 17. [Full Text]|[PubMed]

2011

Chang Y, Moore PS. Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol. Annu Rev Pathol. 2012;7:123-44. doi: 10.1146/annurev-pathol-011110-130227. Epub 2011 Sep 13. [Full Text]|[PubMed]

Dresang LR, Teuton JR, Feng H, Jacobs JM, Camp II DG, Purvine SO, Gritsenko MA, Li Z, Smith RD, Sudgden B, Moore PS, Chang Y. Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes. BMC Genomics 2011; 12(1):625. [Full Text]|[PubMed]

Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS. Merkel Cell Polyomavirus Small T Antigen Is a PP2A-independent Human Oncoprotein Targeting the Translation Regulator 4E-BP1. J Clin Invest, 2011 doi:10.1172/JCI46323. [Full Text]|[PubMed]

Feng H, Kwun HJ, Liu X, Gjoerup O, Stolz DB, Chang Y, Moore PS. Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One, 2011 6(7): e22468.[Full Text]|[PubMed]

Tolstov YL, Knauer A, Chen JG, Kensler TW, Kingsley LA, Moore PS, Chang Y. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis2011 17(8). [Full Text]|[PubMed]

Liu X, Hein J, Richardson SCW, Basse PH, Moore PS, Gjoerup O, Chang Y. Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human VAM6P to the nucleus. J Biol Chem, 2011 May 13;286(19):17079-90[Full Text]|[PubMed]

Moore PS, Chang Y. KSHV: forgotten but not gone. Blood, 2011 117(26): 6973-6974. [Full Text]|[PubMed]

Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan P, Bullock P, Chang Y, Moore PS, Bohm A. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Bio, 2011 409(4): 529-542. [Full Text]|[PubMed]

Kwun HJ, Ramos da Silva S, Qin H, Ferris RL, Tan R, Chang Y, Moore PS. The central repeat domain 1 of Kaposi’s sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation.Virology, 2011 Apr 10;412(2):357-65.[Full Text]|[PubMed]

Schrama D1, Peitsch WK, Zapatka M, Kneitz H, Houben R, Eib S, Haferkamp S, Moore PS, Shuda M, Thompson JF, Trefzer U, Pföhler C, Scolyer RA, Becker JC. Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma. J Invest Dermatol. 2011 Aug;131(8):1631-8. doi: 10.1038/jid.2011.115. Epub 2011 May 12. [Full Text]| [PubMed]

2010

Reisinger DM, Shiffer JD, Cognetta Jr. AB, Chang Y, and Moore PS. Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma. J Am Acad Dermatol, 2010 63(3):400-403. [Full Text]|[PubMed]

Houben R, Shuda M, Weinkam R, Schrama D, Feng H, Chang Y, Moore PS, Becker JC. Merkel cell polyomavirus infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol, 2010 84:7064-7072.[Full Text]|[PubMed]

Tolstov YL, Arora R, Scudiere SC, Busam K, Chaudhary PM, Chang Y, Moore PS. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood, 2010 115(23): 4973-4. [Full Text]|[PubMed]

Kim S, Li Z, Moore PS, Monaghan A, Chang Y, Nichols M, John B. A sensitive nonradioactive northern blot method to detect small RNAs. Nuc Acids Research, 2010 Apr 1;38(7):e98. Epub 2010 Jan 15. [Full Text]|[PubMed]

Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer, 2010 Dec. 10(12): 878-889. [Full Text]|[PubMed]

Kaae J, Hansen AV, Biggar RJ, Boyed HA, Moore PS, Wohlfahrt J, Melbye M. Merkel Cell Carcinoma: Incidence, Mortality, and Risk of Other Cancers. J Natl Cancer Inst2010 102(11): 793-801[Full Text]|[PubMed]

Gjoerup O, Chang Y. Update on human polyomaviruses and cancer. Adv Cancer Res.2010 106:1-51. [PubMed]

2009

Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, Chang Y. The minimum replication origin of Merkel cell polyomavirus has a unique large T antigen loading architecture and requires small T antigen expression for optimal replication. J Virol 2009; 83(23):12118-28. [Full Text] | [PubMed]

Li, Z., Kim, S. W., Lin, Y., Moore, P. S., Chang, Y., John, B. Characterization of viral and human RNAs smaller than canonical microRNAs. J Virol, 2009 Dec;83(24):12751-58.[PubMed]

Pastrana, DV, Tolstov YL, Becker JC, Moore PS, Chang Y, Buck CB. Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog, 2009 Sept;5(9):e1000578. [Full Text]|[PubMed]

Tolstov Y, Pastrana D, Feng H, Becker J, Jenkins F, Moschos S, Chang Y, Buck C, Moore PS. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer, 2009 125:1250-1256. [Full Text]|[PubMed]

Shuda, M., R. Arora, H. J. Kwun, H. Feng, R. Sarid, M. T. Fernandez-Figueras, Y. Tolstov, O. Gjoerup, M. M. Mansukhani, S. H. Swerdlow, P. M. Chaudhary, J. M. Kirkwood, M. A. Nalesnik, J. A. Kant, L. M. Weiss, P. S. Moore, and Y. Chang. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer2009 125:1243-9. [Full Text]|[PubMed]

Busam K, Jungbluth AA, Rekhtman N, Coit D, Pulitzer M, Bini JM, Arora R, Hanson NC, Tassello JA, Frosina D, Moore PS, Chang Y. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas.Am J Surg Path, 2009 Sep;33(9):1378-85. [Full Text]|[PubMed]

Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus; role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood, 2009 113(22):5660-8.[Full Text]|[PubMed]

Shuda M, Moore PS. DISSENT: Lombardi VC et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science. 2009 Oct 23; 326-585-9. Faculty of 1000. 2010. F1000.com/1166366.

Moschos S, Chang Y, and Moore PS. Merkel Cell Polyomavirus: The Seventh Human Cancer Virus? The Melanoma Letter, 2009 Summer;27(2). [Full Text]

2008

Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008 21;105(42):16272-7. [Full Text]|[PubMed]

Feng H, Shuda M, Chang Y, Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science2008 319(5866): 1096-1100. [Full Text]| [PubMed]  

2007

Jacobs SA, Vidnovic N, Patel H, Soma LA, Chang Y, Bass N, Swerdlow SH. Durable remission of HIV-negative, Kaposi’s sarcoma herpes virus-associated multicentric Castleman disease in patients with rheumatoid arthritis treated with methotrexate. Clin Rheumatol 2007; 26(7):1148-50.

Feng H, Taylor JL, Benos PV, Newton R, Waddell K, Lucas SB, Chang Y, and Moore PS. Human Transcriptome subtraction using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol. 2007 Oct:81 (20):11332-40.[Full Text]|[PubMed]

Moore PS, Chang Y, Jaffe H. Transmission of human herpesvirus 8 by blood transfusion (letter). N Engl J Med2007; 356:88. [PubMed]

Kwun H, Ramos da Silva S, Shaw I, Blake N, Moore PS, Chang Y. KSHV LANA1 mimics EBV EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol2007;81 (15):8225-35. [Full Text]|[PubMed]

Kwun HJ1, da Silva SR, Shah IM, Blake N, Moore PS, Chang Y. Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol. 2007 Aug;81(15):8225-35. Epub 2007 May 23. [Full Text]|[PubMed]

2006

Laney AS, Peters J., Manzi S., Kingsley L., Chang Y., Moore P.S. Use of a Multiantigen Detection Algorithm for Diagnosis of Kaposi’s Sarcoma-Associated Herpesvirus Infection. J Clin Micro2006 Oct;44(10):3734-41. [Full Text]|[PubMed]

2005

Laney AS, De Marco T, Peters JS, Malloy M, Teehankee C, Moore PS, Chang Y. Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest2005; 127(3):762-7.[Full Text]|[PubMed]

Corte-Real S, Collins C, Aires da Silva F, Simas JP, Barbas C, Chang Y, Moore P, Goncalves J. Intrabodies targeting the Kaposi’s sarcoma-associated herpesvirus latency antigen inhibit viral persistence. Blood2005; 106(12):3797-802.[Full Text]|[PubMed]

Taylor JL, Bennett HN, Snyder BA, Moore PS, and Chang Y. Transcriptional analysis of the latent and inducible KSHV transcripts in the K4-K7 region. J Virol2005; 79(24):15099-106. [Full Text]| [PubMed]

2004

Kourí V1, Eng SM, Rodríguez ME, Resik S, Orraca O, Moore PS, Chang Y. Seroprevalence of Kaposi’s sarcoma-associated herpesvirus in various populations in Cuba. Rev Panam Salud Publica. 2004 May;15(5):320-5. [PubMed]

2003

Moore PS, Chang Y. Kaposi’s Sarcoma-Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin? Ann Rev Microbiol. 2003; 57:609-39. [Full Text]|[PubMed]

Fejér G1, Medveczky MM, Horvath E, Lane B, Chang Y, Medveczky PG. The latency-associated nuclear antigen of Kaposi’s sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. J Gen Virol. 2003 Jun;84(Pt 6):1451-62. [Full Text]|[PubMed]

2002

Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science2002; 298:1432-5. [Full Text]|[Supplemental Material]|[PubMed]

2001

Markowitz GS1, Williams GS, Chang Y, Hardy MA, Saouaf R, D’Agati VD. A novel etiology of renal allograft dysfunction. Am J Kidney Dis. 2001 Sep;38(3):658-63. [Full Text]|[PubMed]

Navenot JM1, Wang ZX, Trent JO, Murray JL, Hu QX, DeLeeuw L, Moore PS, Chang Y, Peiper SC. Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelopeglycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding. J Mol Biol. 2001 Nov 9;313(5):1181-93. [Full Text]|[PubMed]

Boshoff C, Chang Y. Kaposi’ sarcoma-associated herpesvirus: A new DNA tumor virus. Annu Rev Med2001; 52:453-470.[Full Text]|[PubMed]

Moore PS, Chang Y. Molecular virology of Kaposi’s sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci2001; 356:499-516. [Full Text]|[PubMed]

Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. Kaposi’s sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol2001; 75:429-3.[Full Text]|[PubMed]

2000

Antman K, Chang Y. Kaposi’s sarcoma. N Engl J Med2000; 342:1027-38.[Full Text][PubMed]

Olsen SJ, Sarid R, Chang Y, Moore PS. Evaluation of the latency-associated nuclear antigen (ORF73) of Kaposi’s sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay. J Infect Dis2000; 182:306-10.[Full Text]|[PubMed]

Parravicini C, Chandran B, Corbellino M, Berti E, Paulli M, Moore PS, Chang Y. Differential viral protein expression in Kaposi’s sarcoma-associated herpesvirus-infected diseases: Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. Am J Pathol2000; 156:743-9.[Full Text]|[PubMed]

Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Changry D. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood2000; 95:1151-7.[Full Text]|[PubMed]

J Iscovich 1 , A Fischbein, J Fisher-Fischbein, L S Freedman, S M Eng, P Boffetta , A Vudovich, C Glasman, R Goldschmidt, M Livingston, B Heger-Maslansky, P Brennan, P S Moore. Seroprevalence of Kaposi’s Sarcoma-Associated Herpesvirus in Healthy Adults in Israel. Anticancer Res 20 (3B), 2119-2122.

1999

Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G. Involvement of IL-10 and viral IL-6 in the spontaneous growth of Kaposi’s sarcoma herpesvirus-infected body cavity lymphoma cells. Blood.1999; 94(8):2871-79. [Full Text]|[PubMed]

Osborne J1, Moore PS, Chang Y. KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathwaysHum Immunol. 1999 Oct;60(10):921-7. [Full Text]|[PubMed]

Matsushima AY1, Strauchen JA, Lee G, Scigliano E, Hale EE, Weisse MT, Burstein D, Kamel O, Moore PS, Chang Y. Posttransplantation plasmacytic proliferations related to Kaposi’s sarcoma-associated herpesvirusAm J Surg Pathol. 1999 Nov;23(11):1393-400. [Full Text]|[PubMed]

Tarte K1, Chang Y, Klein B. Kaposi’s sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality.Blood. 1999 May 15;93(10):3159-63; discussion 3163-4. [Full Text]|[PubMed]

Aoki Y, Jaffe ES, Chang Y, Jones K, Teruya-Feldstein J, Moore PS, et al. Angiogenesis and hematopoiesis induced by Kaposi’s sarcoma-associated herpesvirus-encoded interleukin-6. Blood1999;93(12):4034-43.[Full Text]|[PubMed]

Sarid R, Wiezorek JS, Moore PS, Chang Y. Characterization and cell cycle regulation of the major Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J Virol1999; 73:1438-46.[Full Text]|[PubMed]

Schulz TF, Moore PS. Kaposi’s sarcoma-associated herpesvirus: a new human tumor virus, but how? Trends Microbiol. 1999;7(5):196-200. [Full Text]|[PubMed]

Grulich AE1, Olsen SJ, Luo K, Hendry O, Cunningham P, Cooper DA, Gao SJ, Chang Y, Moore PS, Kaldor JM. Kaposi’s sarcoma-associated herpesvirus: a sexually transmissible infectionJ Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):387-93. [Full Text]|[PubMed]

1998

Tarte K, Olsen SJ, Rossi JF, Legouffe E, Lu ZY, Jourdan M, Chang Y, Klein B. Kaposi’s sarcoma-associated herpesvirus is not detected with immunosuppression in multiple myeloma. Blood. 1998 Sep 15;92(6):2186-8.  [Full Text]|[PubMed]

Olsen SJ1, Chang Y, Moore PS, Biggar RJ, Melbye M. Increasing Kaposi’s sarcomaassociated herpesvirus seroprevalence with age in a highly Kaposi’s sarcoma endemic region, Zambia in 1985AIDS. 1998 Oct 1;12(14):1921-5. [Full Text|[PubMed]

Kambham N1, Chang Y, Matsushima AY. Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arising in duraClin Neuropathol. 1998 Nov-Dec;17(6):311-7. [PubMed]

Tarte K1, Olsen SJ, Yang Lu Z, Legouffe E, Rossi JF, Chang Y, Klein B. Clinical-grade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi’s sarcoma-associated herpesvirus. Blood. 1998 Mar 15;91(6):1852-7. [Full Text]|[PubMed]

Boshoff C1, Gao SJ, Healy LE, Matthews S, Thomas AJ, Coignet L, Warnke RA, Strauchen JA, Matutes E, Kamel OW, Moore PS, Weiss RA, Chang Y. Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID miceBlood. 1998 Mar 1;91(5):1671-9. [Full Text]|[PubMed]

Moore PS, Chang Y. Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV. Trends Genetics1998;14(4):144-50. [PubMed]

Olsen SJ, Tarte K, Sherman W, et al. Evidence against KSHV infection in the pathogenesis of multiple myeloma. Virus Res1998; 57:197-202.[Full Text]|[PubMed]

Moore, PS. Human herpesvirus 8 variants (or KSHV and Waterbuffaloes). Lancet1998; 351:Feb. 28 issue. [Full Text]|[PubMed]

Sarid R, Flore O. Bohenzky RA, Chang Y. Moore PS. Transcriptional mapping of the Kaposi’s sarcoma-associated herpesvirus (KSHV) genome in the body cavity-based lymphoma cell line BC-1. J. Virol., 1998: 72:1005-12.[Full Text]|[PubMed]

Sanders EJ1, Marfin AA, Tukei PM, Kuria G, Ademba G, Agata NN, Ouma JO, Cropp CB, Karabatsos N, Reiter P, Moore PS, Gubler DJ. First recorded outbreak of yellow fever in Kenya, 1992-1993. I. Epidemiologic investigations. Am J Trop Med Hyg. 1998 Oct;59(4):644-9. [Full Text]|[PubMed]

1997

Gao SJ, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway. Oncogene1997; 15:1979-86.[Full Text]|[PubMed]

Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani M, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA. Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science1997; 278:290-4.[Full Text]|[PubMed]

Gottfried JA1, Mayer SA, Shungu DC, Chang Y, Duyn JH. Delayed posthypoxic demyelination. Association with arylsulfatase A deficiency and lacticacidosis on proton MR spectroscopyNeurology. 1997 Nov;49(5):1400-4. [PubMed]

Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi’s sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med. 1997; 3:293-8.[Full Text]|[PubMed]

Schwartz TH1, Chang Y, Stein BM. Unusual intramedullary vascular lesion: report of two casesNeurosurgery. 1997 Jun;40(6):1295-301. [Full Text]|[PubMed]

Godden-Kent D1, Talbot SJ, Boshoff C, Chang Y, Moore P, Weiss RA, Mittnacht S. The cyclin encoded by Kaposi’s sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1J Virol. 1997 Jun;71(6):4193-8. [Full Text]|[PubMed]

Miller G1, Heston L, Grogan E, Gradoville L, Rigsby M, Sun R, Shedd D, Kushnaryov VM, Grossberg S, Chang Y. Selective switch between latency and lytic replication of Kaposi’s sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cellsJ Virol. 1997 Jan;71(1):314-24. [Full Text]|[PubMed]

Parravicini C1, Corbellino M, Paulli M, Magrini U, Lazzarino M, Moore PS, Chang Y. Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman’s diseaseAm J Pathol. 1997 Dec;151(6):1517-22. [Full Text]|[PubMed]

Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi’s sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Journal of Biological Chemistry. 1997; 272:19625-31.[Full Text]|[PubMed]

Rainbow L, Platt GM, Simpson GR, Sarid R, Gao SJ, Stoiber H, Herrington CS, Moore PS, Schulz TF. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol. 1997; 71:5915-21. [Full Text]|[PubMed]

Parravicini C, Olsen SJ, Capra M, Poli F, Sirchia G, Gao SJ, Berti E, Nocera A, Rossi E, Bestetti G, Pizzuto M, Galli M, Moroni M, Moore PS, Corbellino M. Risk of Kaposi’s sarcoma-associated herpesvirus transmission from donor allografts among Italian posttransplant Kaposi’s sarcoma patients. Blood. 1997; 90:2826-9.[Full Text]|[PubMed]

1996

Chang Y1, Moore PS. Kaposi’s Sarcoma (KS)-associated herpesvirus and its role in KSInfect Agents Dis. 1996 Oct;5(4):215-22. [Full Text]|[PubMed]

Strauchen JA1, Hauser AD, Burstein D, Jimenez R, Moore PS, Chang Y. Body cavity-based malignant lymphoma containing Kaposi sarcoma-associated herpesvirus in an HIV-negative man with previous Kaposi sarcomaAnn Intern Med. 1996 Nov 15;125(10):822-5. [Full Text|[PubMed]

Cesarman E1, Nador RG, Bai F, Bohenzky RA, Russo JJ, Moore PS, Chang Y, Knowles DM. Kaposi’s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin homologs which are expressed in Kaposi’s sarcoma and malignant lymphomaJ Virol. 1996 Nov;70(11):8218-23. [Full Text]|[PubMed]

Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, Levy JA, Gao SJ, Chang Y, Moore PS. Antibodies to butyrate inducible antigens of Kaposi’s sarcoma-associated herpesvirus in HIV-1 infected patients. New Eng. J. Med., 1996; 334:1292-7.[Full Text]|[PubMed]

Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. New Eng. J. Med., 1996; 335:233-41. [Full Text]|[PubMed]

Gaidano G1, Cechova K, Chang Y, Moore PS, Knowles DM, Dalla-Favera R. Establishment of AIDS-related lymphoma cell lines from lymphomatous effusionsLeukemia. 1996 Jul;10(7):1237-40. [PubMed]

Chang Y1, Ziegler J, Wabinga H, Katangole-Mbidde E, Boshoff C, Schulz T, Whitby D, Maddalena D, Jaffe HW, Weiss RA, Moore PS. Kaposi’s sarcoma-associated herpesvirus and Kaposi’s sarcoma in Africa. Uganda Kaposi’s Sarcoma Study Group. Arch Intern Med. 1996 Jan 22;156(2):202-4. [Full Text]|[PubMed]

Moore PS, Kingsley LA, Holmberg SD, Spira T, Gupta P, Hoover DR, Parry JP, Conley LJ, Jaffe HW, Chang Y. Kaposi’s sarcoma-associated herpesvirus infection prior to onset of Kaposi’s sarcoma. AIDS. 1996 Feb;10(2):175-80.[Full Text]|[PubMed]

Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature. 1996; 382:410.[Full Text]|[PubMed]

PS Moore, SJ Gao, G Dominguez, E Cesarman, O Lungu, DM Knowles, R Garber, PE Pellett, DJ McGeoch and Y Chang. Primary characterization of a herpesvirus agent associated with Kaposi’s sarcoma [published erratum appears in J. Virol 1996 70(12): 9083]. J. Virol. 1996; 70: 549-58. [Full Text]|[PubMed]

Simpson GR, Schulz TF, Whitby D, Cook PM, Boshoff C, Rainbow L, Howard MR, Gao SJ, Bohenzky RA, Simmonds P, Lee C, de Ruiter A, Hatzakis A, Tedder RS, Weller IV, Weiss RA, Moore PS. Prevalence of Kaposi’s sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet. 1996; 348:1133-8.[Full Text]|[PubMed]

Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science. 1996; 274:1739-44.[Full Text]|[PubMed]

Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. Nucleotide sequence of Kaposi’s sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA. 1996; 93:148627.[Full Text]|[PubMed] 

Gao SJ, Moore PS. Molecular approaches to the identification of unculturable infectious agents. Emerging Infect Dis1996; 2:159-67. [Full Text]|[PubMed]

Gao SJ, Kingsley L, Li M, Zhang W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chan.g Y, Moore PS KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi’s sarcoma. Nature Medicine. 1996; 2:925-28. [Full Text]|[PubMed]

*Jon Cohen. Controversy: Is KS Really Caused By New Herpesvirus? Science 1995; 268:1847-8. Moore PS, Chang Y. Kaposi sarcoma findings (or Hakuin Ekaku’s koan: “Is that so?”) Science 1995; 270:15 and Jon Cohen. Reports Bolster Viral Cause of KS. Science 1996; 273:573. [Full Text]

Boshoff C, Talbot S, Kennedy M, O’Leary J, Schulz T, Chang Y. HHV8 and skin cancers in immunosuppressed patients. Lancet. 1996 Jul 13;348(9020):138.

1995

Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85.  [Full Text]|[PubMed]

Cesarman E, Chang Y, Moore PS, Said J, Knowles DM. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences are detectable in AIDS-related body cavity based non-Hodgkin’s lymphomas. New Eng J Med, 1995; 332:1186-91.[Full Text]|[PubMed]

E Cesarman, PS Moore, PH Rao, G Inghirami, DM Knowles, and Y Chang. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi’s sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood, Oct 1995; 86: 2708 – 2714. [Full Text] |[PubMed]

Marfin AA1, Sporrer J, Moore PS, Siefkin AD. Risk factors for adverse outcome in persons with pneumococcal pneumonia. Chest. 1995 Feb;107(2):457-62. [Full Text]|[PubMed]

1994

*Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 265:1865-69.[Full Text]|[PubMed]

Chang Y1, Albright S, Lee F. Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol. 1994 Jun;52(1):9-17. [PubMed]

Marfin AA1, Moore J, Collins C, Biellik R, Kattel U, Toole MJ, Moore PS. Infectious disease surveillance during emergency relief to Bhutanese refugees in Nepal. JAMA. 1994 Aug 3;272(5):377-81. [PubMed]

1993

Moore PS, Allen S, Sowell AL, Van de Perre P, Huff DL, Serufilira A, Nsengumuremyi F, Hulley SB. Role of nutritional status and weight loss in HIV seroconversion among Rwandan women.  J Acquir Immune Defic Syndr 1993; 6(6):611-616. [PubMed]

Marfin AA, Bleed DM, Lofgren JP, Olin AC, Savage HM, Smith GC, Moore PS, Karabatsos N, Tsai TF. Epidemiologic aspects of a St. Louis encephalitis epidemic in Jefferson County Arkansas, 1991. Am J Trop Med Hyg 1993; 49(1):30-37. [PubMed]

Moore PS, Plikaytis BD, Bolan GA, Oxtoby MJ, Yada A, Zoubga A, Reingold AL, Broome CV. Detection of meningitis epidemics in Africa: a population-based analysis. Int J Epidemiol 1992; 21(1):155-162. [PubMed]

Chang Y1, Twiss JL, Horoupian DS, Caldwell SA, Johnston KM. Inherited syndrome of infantile olivopontocerebellar atrophy, micronodular cirrhosis, and renal tubular microcysts: review of the literature and a report of an additional case. Acta Neuropathol. 1993;86(4):399-404. [PubMed]

Chang Y1, Horoupian DS, Jordan J, Steinberg G. Localized hypertrophic mononeuropathy of the trigeminal nerve. Arch Pathol Lab Med. 1993 Feb;117(2):170-6. [PubMed]

Chang Y1, Kargas SA, Goates JJ, Horoupian DS. Intraventricular and subarachnoid hemorrhage resulting from necrotizing vasculitis of the choroid plexus in a patient with Churg-Strauss syndrome. Clin Neuropathol. 1993 Mar-Apr;12(2):84-7. [PubMed]

Paul WS1, Moore PS, Karabatsos N, Flood SP, Yamada S, Jackson T, Tsai TF. Outbreak of Japanese encephalitis on the island of Saipan, 1990. J Infect Dis. 1993 May;167(5):1053-8. [PubMed]

Moore PS1, Marfin AA, Quenemoen LE, Gessner BD, Ayub YS, Miller DS, Sullivan KM, Toole MJ. Mortality rates in displaced and resident populations of central Somalia during 1992 famine. Lancet. 1993 Apr 10;341(8850):935-8. [PubMed]

Public Health Service Surveillance of the health status of Butanese refugees – Nepal, 1992. MMWR 1193:14-17.

Public Health Service Arboviral diseases – United States, 1992. MMWR 1993; 42:467-468.

1992

Achtman M, Kusecek B, Morelli G, Eickmann K, Wang JF, Crowe B, Wall RA, Hassan-King M, Moore PS, Zollinger W. A comparison of the variable antigens expressed by clone IV-1 and subgroup III of Neisseria meningitidis serogroup A. J Infect Dis 1992; 165(1):53-68. [PubMed]

Jordan JE1, Lane B, Marks M, Chang Y, Weinberger M. Cranial hypertrophic interstitial neuropathy. AJNR Am J Neuroradiol. 1992 Nov-Dec;13(6):1552-4. [PubMed]

Public Health Service Arboviral encephalitis: United States, 1991. MMWR 1992; 41:545-548.

Public Health Service Population-based mortality assessment-Baidoa and Afgoi, Somalia, 1992. MMWR 1992; 41:913:917.

1991

Chang Y1, Horoupian DS, Lane B, Fross RD, Smyth LT Jr, Seiling RJ. Inflammatory pseudotumor of the choroid plexus in Sjögren’s diseaseNeurosurgery. 1991 Aug;29(2):287-90. [PubMed]

Herrick MK1, Chang Y, Horoupian DS, Lombard CM, Adornato BT. L-tryptophan and the eosinophilia-myalgia syndrome: pathologic findings in eight patients. Hum Pathol. 1991 Jan;22(1):12-21. [PubMed]

Parsonnet J1, Vandersteen D, Goates J, Sibley RK, Pritikin J, Chang Y. Helicobacter pylori infection in intestinal– and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst. 1991 May 1;83(9):640-3. [PubMed]

Gillespie SM1, Chang Y, Lemp G, Arthur R, Buchbinder S, Steimle A, Baumgartner J, Rando T, Neal D, Rutherford G, et al. Progressive multifocal leukoencephalopathy in persons infected with human immunodeficiency virus, San Francisco, 1981-1989. Ann Neurol. 1991 Oct;30(4):597-604. [PubMed]

Parsonnet J1, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991 Oct 17;325(16):1127-31. [PubMed]

Moore PS1, Plikaytis BD, Bolan GA, Oxtoby MJ, Yada A, Zoubga A, Reingold AL, Broome CV. Detection of meningitis epidemics in Africa: a population-based analysis. Int J Epidemiol. 1992 Feb;21(1):155-62. [PubMed]

Public Health Service St. Louis encephalitis outbreak-Arkansas. MMWR 1991; 40:605-607.

Johnson SE1, Swaminathan B, Moore P, Broome CV, Parvin M. Borrelia burgdorferi: survival in experimentally infected human blood processed for transfusion. J Infect Dis. 1990 Aug;162(2):557-9. [PubMed]

1990

Chang Y1, Soffer D, Horoupian DS, Weiss LM. Evolution of post-natal herpes simplex virus encephalitis to multicystic encephalopathy. Acta Neuropathol. 1990;80(6):666-70. [Full Text]|[PubMed]

Chang Y1, Dehner LP, Egbert B. Primary cutaneous rhabdomyosarcomaAm J Surg Pathol. 1990 Oct;14(10):977-82. [PubMed]

Moore PS1, Hierholzer J, DeWitt W, Gouan K, Djoré D, Lippeveld T, Plikaytis B, Broome CV. Respiratory viruses and mycoplasma as cofactors for epidemic group A meningococcal meningitis. JAMA. 1990 Sep 12;264(10):1271-5. [PubMed]

1989

Tsai TF, Bailey RE, Moore PSNational surveillance of Lyme disease, 1987-1988. Conn Med. 1989 Jun;53(6):324-6. [PubMed]

Moore PS1, Reeves MW, Schwartz B, Gellin BG, Broome CV. Intercontinental spread of an epidemic group A Neisseria meningitidis strain. Lancet. 1989 Jul 29;2(8657):260-3. [PubMed]

Cannon RO1, Schmid GP, Moore PS, Pappaioanou M. Human immunodeficiency virus (HIV) seroprevalence in persons attending STD clinics in the United States, 1985-1987. Sex Transm Dis. 1989 Oct-Dec;16(4):184-9. [PubMed]

1988

Gown AM1, Boyd HC, Chang Y, Ferguson M, Reichler B, Tippens D. Smooth muscle cells can express cytokeratins of “simple” epithelium. Immunocytochemical and biochemical studies in vitro and in vivo. Am J Pathol. 1988 Aug;132(2):223-32. [Full Text]|[PubMed]

Public Health Service Human Immunodeficiency virus infection in the United States; A review of current knowledge. MMWR 1988; 36(Supplement):1-48.

Moore PS1, Harrison LH, Telzak EE, Ajello GW, Broome CV. Group A meningococcal carriage in travelers returning from Saudi Arabia. JAMA. 1988 Nov 11;260(18):2686-9. [PubMed]

1979

Kamaya H, Ueda I, Moore PS, Eyring H. Antagonism between high pressure and anesthetics in the thermal phase-transition of dipalmitoylphosphatidylcholine bilayerBiochim Biophys Acta. 1979 Jan 5;550(1):131-7. [PubMed]

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