We are working hard to make new discoveries about Merkel Cell Polyomavirus. If you or someone you love has been diagnosed with MCC, check out our page for patients and friends for resources and information.

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KSHV LANA generates novel cytoplasmic proteins through non canonical translation initiation J Virol. 2012 Dec 19


Dr. Reety Arora defends her PhD thesis and publishes a killer paper in Science Translational Medicine. Congratulations, Reety! Badhai ho!


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Some Recent Chang-Moore Publications

Celestino Velásquez, Erdong Cheng, Masahiro Shuda, Paula J. Lee-Oesterreich, Lisa Pogge von Strandmann, Marina A. Gritsenko, Jon M. Jacobs, Patrick S. Moore, and Yuan Chang. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. PNAS 2016 113 (30) 8466-8471; published ahead of print July 11, 2016, doi:10.1073/pnas.1607768113.[Full Text] | [Link]

Tuna Toptan, Samuel A. Yousem, Jonhan Ho, Yuki Matsushima, Laura P. Stabile, Maria-Teresa Fernandez-Figueras, Rohit Bhargava, Akihide Ryo, Patrick S. Moore, and Yuan Chang. Survey for human polyomaviruses in cancer. JCI Insight. 2016;1(2):e85562. doi:10.1172/jci.insight.85562.[Full Text] | [Link]

Shuda M, Guastafierro A, Geng X, Shuda Y, Ostrowski SM, Lukianov S, et al. Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. PLoS One 10(11): e0142329. doi:10.1371/journal.pone.0142329. [Full Text] | [Link]

Masahiro Shuda, Yuan Chang, Patrick Moore. Mitotic 4E-BP1 hyperphosphorylation and cap-dependent translation. Cell Cycle. 2015;14(19):3005-6. doi: 10.1080/15384101.2015.1084192.[Full Text]| [Link]

Richards KF, Guastafierro A, Shuda M, Toptan T, Moore PS, Chang Y. Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression. J Gen Virol. 2015 Dec;96(12):3532-44.[Full Text]| [Link]

Masahiro Shuda, Celestino Velásquez, Erdong Cheng, Daniel G. Cordek, Hyun Jin Kwun, Yuan Chang, and Patrick S. Moore. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 Apr 16. pii: 201505787. [Full Text] | [Link]

Lachmann J, Glaubke E, Moore PS, Ungermann C. The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET. Cell Logist. 2014 Oct 2;4(4):e970840. eCollection 2014 Oct-Dec.[Full Text] | [Link]

Wendzicki JA, Moore PS, Chang Y. Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol. 2015 Feb 11;11C:38-43. doi: 10.1016/j.coviro.2015.01.009. [Full Text] | [Link]

Kwun HJ, Shuda M, Camacho CJ, Gamper AM, Thant M, Chang Y, Moore PS. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J Virol. 2015 Apr 15;89(8):4191-200. doi: 10.1128/JVI.00157-15. [Full Text]|[Link]

Chang Y, Moore P. Twenty years of KSHV. Viruses. 2014 Nov 7;6(11):4258-64. doi: 10.3390/v6114258. [Full Text]|[Pubmed]

Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y. Human DNA Tumor Viruses Generate Alternative Reading Frame Proteins Through Repeat Sequence Coding. Proc Nat Acad Sci USA 2014. [Full Text]|[PubMed]

Ho J, Jedrych JJ, Feng H, Natalie AA, Grandinetti L, Mirvish E, Crespo MM, Yadav D, Fasanella KE, Proskell S, Kuan SF, Pastrana DV, Buck CB, Shuda Y, Moore PS, Chang Y. Human Polyomavirus 7-associated Pruritic Rash and Viremia in Transplant Recipients. J Infect Dis 2014. [PubMed]

Shuda M, Chang Y, Moore PS. Merkel Cell Polyomavirus Positive Merkel Cell Carcinoma Requires Viral Small T Antigen for Cell Proliferation. JID 2014 May;134(5):1479-81.[Full Text]|[PubMed]

Dresang LR, Guastafierro A, Arora R, Normolle D, Chang Y, Moore PS. Response of Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Xenografts to a Survivin Inhibitor.PLoS ONE.[Full Text]|[PubMed]

Kwun HJ, Shuda M, Feng H, Camacho CJ, Moore PS, Chang Y. Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7. Cell Host and Microbe 2013; 14(2):125-135. [Full Text] | [PubMed]

Toptan T, Fonseca L, Kwun HJ, Chang Y, Moore PS. Complex Alternative Cytoplasmic Protein Isoforms of the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Generated through Noncanonical Translation Initiation. J Virol. 2013 Mar.[Full Text] | [PubMed]

Arora R, Chang Y, Moore PS. MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol. 2012 Jun 17. [Full Text] | [PubMed]

Li Z, Ender C, Meister G, Moore PS, Chang Y, John B. Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res. 2012 Apr 9. [Full Text] | [PubMed]

Chang Y, Moore PS. Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol. 2012;7:123-44. Epub 2011 Sep 13. [PubMed]

Arora R, Shuda M, Guastafierro A, Feng H, Toptan T, Tolstov Y, Normolle D, Vollmer LL, Vogt A, Dömling A, Brodsky JL, Chang Y, Moore PS. Survivin is a therapeutic target in merkel cell carcinoma. Sci Transl Med. 2012 May 9;4(133):133ra56. [Full Text] [PubMed]

Dresang LR, Teuton JR, Feng H, Jacobs JM, Camp II DG, Purvine SO, Gritsenko MA, Li Z, Smith RD, Sudgden B, Moore PS, Chang Y. Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes. BMC Genomics 2011; 12(1):625. [Full Text] [PubMed]

Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS. Merkel Cell Polyomavirus Small T Antigen Is a PP2A-independent Human Oncoprotein Targeting the Translation Regulator 4E-BP1. J Clin Invest, 2011 doi:10.1172/JCI46323. [Full Text] [PubMed]

Feng H, Kwun HJ, Liu X, Gjoerup O, Stolz DB, Chang Y, Moore PS. Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One, 2011 6(7): e22468. [Full Text] [PubMed]

Tolstov YL, Knauer A, Chen JG, Kensler TW, Kingsley LA, Moore PS, Chang Y. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis, 2011 17(8). [Full Text] [PubMed]

Moore PS, Chang Y. KSHV: forgotten but not gone. Blood, 2011 117(26): 6973-6974. [Full Text] [PubMed]

Harrison XJ, Meinke G, Kwun HJ, Rogalin H, Phelan P, Bullock P, Chang Y, Moore PS, Bohm A. Asymetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Bio, 2011 409(4): 529-542. [Full Text] [PubMed]

Liu X, Hein J, Richardson SCW, Basse PH, Moore PS, Gjoerup O, Chang Y. Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human VAM6P to the nucleus. J Biol Chem, 2011 May 13;286(19):17079-90. [Full Text] [PubMed]

Kwun HJ, Ramos da Silva S, Qin H, Ferris RL, Tan R, Chang Y, Moore PS. The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation. Virology, 2011 Apr 10;412(2):357-65. [Full Text] [PubMed]

Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer, 2010 Dec. 10(12): 878-889. [Full Text] [PubMed]

Reisinger DM, Shiffer JD, Cognetta Jr. AB, Chang Y, and Moore PS. Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma, J Am Acad Dermatol, 2010 63(3):400-403. [Full Text] [PubMed]

Houben R, Shuda M, Weinkam R, Schrama D, Feng H, Chang Y, Moore PS, Becker JC. Merkel cell polyomavirus infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol, 2010 84:7064-7072. [Full Text] [PubMed]

Tolstov YL, Arora R, Scudiere SC, Busam K, Chaudhary PM, Chang Y, Moore PS. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood, 2010 115(23): 4973-4. [Full Text] [PubMed]

Kaae J, Hansen AV, Biggar RJ, Boyed HA, Moore PS, Wohlfahrt J, Melbye M. Merkel Cell Carcinoma: Incidence, Mortality, and Risk of Other Cancers. J Natl Cancer Inst. 2010 102(11): 793-801.[Full Text] [PubMed]

Gjoerup O, Chang Y. Update on human polyomaviruses and cancer. Adv Cancer Res. 2010 106:1-51. [Full Text] [PubMed]

Kim S, Li Z, Moore PS, Monaghan A, Chang Y, Nichols M, John B. A sensitive nonradioactive northern blot method to detect small RNAs. Nuc Acids Research, 2010 Apr 1;38(7):e98. Epub 2010 Jan 15. [Full Text] [PubMed]

Shuda M, Moore PS. DISSENT: Lombardi VC et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome Science. 2009 Oct 23; 326-585-9. Faculty of 1000 2010. F1000.com/1166366.

Moschos S, Chang Y, and Moore PS. Merkel Cell Polyomavirus: The Seventh Human Cancer Virus? The Melanoma Letter, 2009 Summer;27(2). [Full Text]

Pastrana, DV, Tolstov YL, Becker JC, Moore PS, Chang Y, and Buck CB. Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog, 2009 Sept;5(9):e1000578. [Full Text] [PubMed]

Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, and Chang Y. The minimum replication origin of Merkel cell polyomavirus has a unique large T antigen loading architecture and requires small T antigen expression for optimal replication. J Virol, 2009 Dec;83(23):12118-28. [Full Text] [PubMed]

Li, Z., Kim, S. W., Lin, Y., Moore, P. S., Chang, Y., & John, B. Characterization of viral and human RNAs smaller than canonical microRNAs. J Virol, 2009 Dec;83(24):12751-58. [Full Text] [PubMed]

Busam K, Jungbluth AA, Rekhtman N, Coit D, Pulitzer M, Bini JM, Arora R, Hanson NC, Tassello JA, Frosina D, Moore PS, Chang Y. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Path, 2009 Sep;33(9):1378-85. [Full Text] [PubMed]

Tolstov Y, Pastrana D, Feng H, Becker J, Jenkins F, Moschos S, Chang Y, Buck C, Moore PS. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer, 2009 125:1250-1256. [Full Text] [PubMed]

Shuda, M., R. Arora, H. J. Kwun, H. Feng, R. Sarid, M. T. Fernandez-Figueras, Y. Tolstov, O. Gjoerup, M. M. Mansukhani, S. H. Swerdlow, P. M. Chaudhary, J. M. Kirkwood, M. A. Nalesnik, J. A. Kant, L. M. Weiss, P. S. Moore, and Y. Chang. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 2009 125:1243-9. [Full Text] [PubMed]

Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus; role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood, 2009 113(22):5660-8. [Full Text] [PubMed]

Shuda M, Feng H, Kwun H, Rosen ST, Gjoerup O, Moore PS, Chang Y. T-antigen mutations are a tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci, USA. 2008 21;105(42):16272-7. [Full Text] [PubMed]

Feng H, Shuda M, Chang Y and Moore PS. Clonal Integration of a Polyomavirus in Merkel Cell Carcinoma. Science 2008 319(5866): 1096-1100. [Full Text] [PubMed]

Moore PS, Chang Y, Jaffe H. Transmission of human herpesvirus 8 by blood transfusion (letter). N Engl J Med 2007; 356:88. [PubMed]

Kwun H, Ramos da Silva S, Shaw I, Blake N, Moore PS, Chang Y. KSHV LANA1 mimics EBV EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol 2007;81 (15):8225-35. [Full Text] [PubMed]

Feng H, Taylor JL, Benos PV, Newton R, Waddell K, Lucas SB, Chang Y, and Moore PS. Human Transcriptome subtraction using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol. 2007 Oct:81 (20):11332-40. [Full Text] [PubMed]

Laney AS, Peters J., Manzi S., Kingsley L., Chang Y., Moore P.S. Use of a Multiantigen Detection Algorithm for Diagnosis of Kaposi's Sarcoma-Associated Herpesvirus Infection. J Clin Micro 2006 Oct;44(10):3734-41. [Full Text] [PubMed]

Corte-Real S, Collins C, Aires da Silva F, Simas JP, Barbas C, Chang Y, Moore P, Goncalves J. Intrabodies targeting the Kaposi’s sarcoma-associated herpesvirus latency antigen inhibit viral persistence. Blood 2005; 106(12):3797-802. [Full Text] [PubMed]

Laney AS, De Marco T, Peters JS, Malloy M, Teehankee C, Moore PS, Chang Y. Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest 2005; 127(3):762-7. [Full Text] [PubMed]

Taylor JL, Bennett HN, Snyder BA, Moore PS, and Chang Y. Transcriptional analysis of the latent and inducible KSHV transcripts in the K4-K7 region. J Virol 2005; 79(24):15099-106. [Full Text] [PubMed]

Moore PS, Chang Y. Kaposi‘s Sarcoma-Associated Herpesvirus Immunoevasion and Tumorgensis: Two Sides of the Same Coin? Ann Rev Microbiol. 2003; 57:609-39. [Full Text] [PubMed]

Chatterjee M, Osborne J, Bestetti G, Chang Y. Moore PS. Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity. Science 2002; 298:1432-5. [Full Text] [Supplemental Material] [PubMed]

Boshoff C, Chang Y. Kaposi' sarcoma-associated herpesvirus: A new DNA tumor virus. Annu Rev Med 2001; 52:453-470. [Full Text] [PubMed]

Moore PS, Chang Y. Molecular virology of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci 2001; 356:499-516. [Full Text] [PubMed]

Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol 2001; 75:429-3. [Full Text] [PubMed]

Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med 2000; 342:1027-38. [Full Text] [PubMed]

Olsen SJ, Sarid R, Chang Y, Moore PS. Evaluation of the latency-associated nuclear antigen (ORF73) of Kaposi's sarcoma-associated herpesvirus by peptide mapping and bacterially expressed recombinant western blot assay. J Infect Dis 2000; 182:306-10. [Full Text] [PubMed]

Parravicini C, Chandran B, Corbellino M, Berti E, Paulli M, Moore PS, Chang Y. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 2000; 156:743-9. [Full Text] [PubMed]

Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Changry D. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 2000; 95:1151-7. [Full Text] [PubMed]

Aoki Y, Jaffe ES, Chang Y, Jones K, Teruya-Feldstein J, Moore PS, et al. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 1999;93(12):4034-43. [Full Text] [PubMed]

Jones KD, Aoki Y, Chang Y, Moore PS, Yarchoan R, Tosato G. Involvement of IL-10 and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-infected body cavity lymphoma cells. Blood 1999; 94(8):2871-79. [Full Text] [PubMed]

Schulz TF, Moore PS. Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how? Trends Microbiol.1999;7(5):196-200. [Full Text] [PubMed]

Sarid R, Wiezorek JS, Moore PS, Chang Y. Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J Virol 1999; 73:1438-46. [Full Text] [PubMed]

Moore PS, Chang Y. Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV. Trends Genetics 1998;14(4):144-50. [Full Text] [PubMed]

Olsen SJ, Tarte K, Sherman W, et al. Evidence against KSHV infection in the pathogenesis of multiple myeloma. Virus Res 1998; 57:197-202. [Full Text] [PubMed]

Moore, PS. Human herpesvirus 8 variants (or KSHV and Waterbuffaloes). Lancet 1998; 351:Feb. 28 issue. [Full Text] [PubMed]

Sarid R, Flore O. Bohenzky RA, Chang Y. Moore PS. Transcriptional mapping of the Kaposi's sarcoma-associated herpesvirus (KSHV) genome in the body cavity-based lymphoma cell line BC-1. J. Virol., 1998: 72:1005-12. [Full Text] [PubMed]

Boshoff C, Endo Y, Collins PD, Takeuchi Y, Reeves JD, Schweickart VL, Siani M, Sasaki T, Williams TJ, Gray PW, Moore PS, Chang Y, Weiss RA. Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science 1997; 278:290-4. [Full Text] [PubMed]

Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Journal of Biological Chemistry 1997; 272:19625-31. [Full Text] [PubMed]

Gao SJ, Boshoff C, Jayachandra S, Weiss RA, Chang Y, Moore PS. KSHV ORF K9 (vIRF) is an oncogene that inhibits the interferon signaling pathway. Oncogene 1997; 15:1979-86. [Full Text] [PubMed]

Rainbow L, Platt GM, Simpson GR, Sarid R, Gao SJ, Stoiber H, Herrington CS, Moore PS, Schulz TF. The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 1997; 71:5915-21. [Full Text] [PubMed]

Parravicini C, Olsen SJ, Capra M, Poli F, Sirchia G, Gao SJ, Berti E, Nocera A, Rossi E, Bestetti G, Pizzuto M, Galli M, Moroni M, Moore PS, Corbellino M. Risk of Kaposi's sarcoma-associated herpesvirus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients. Blood 1997; 90:2826-9. [Full Text] [PubMed]

Sarid R, Sato T, Bohenzky RA, Russo JJ, Chang Y. Kaposi's sarcoma-associated herpesvirus encodes a functional bcl-2 homologue. Nature Med 1997; 3:293-8. [Full Text] [PubMed]

Moore PS, Kingsley LA, Holmberg SD, Spira T, Gupta P, Hoover DR, Parry JP, Conley LJ, Jaffe HW, Chang Y. Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS. 1996 Feb;10(2):175-80. [Full Text] [PubMed]

Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden-Kent, Paterson H, Weiss RA, Mittnacht S. Cyclin encoded by KS herpesvirus. Nature 1996; 382:410. [Full Text] [PubMed]

Simpson GR, Schulz TF, Whitby D, Cook PM, Boshoff C, Rainbow L, Howard MR, Gao SJ, Bohenzky RA, Simmonds P, Lee C, de Ruiter A, Hatzakis A, Tedder RS, Weller IV, Weiss RA, Moore PS. Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996; 348:1133-8. [Full Text] [PubMed]

Moore PS, Boshoff C, Weiss RA, Chang Y. Molecular mimicry of human cytokine and cytokine-response pathway genes by KSHV. Science 1996; 274:1739-44. [Full Text] [PubMed]

Russo JJ, Bohenzky RA, Chien M, Chen K, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS. The nucleotide sequence of Kaposi's sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci, USA 1996; 93:148627. [Full Text] [PubMed]

Gao SJ, Moore PS. Molecular approaches to the identification of unculturable infectious agents. Emerging Infect Dis 1996; 2:159-67. [Full Text] [PubMed]

Gao SJ, Kingsley L, Li M, Zhang W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine 1996; 2:925-28. [Full Text] [PubMed]

Gao SJ, Kingsley L, Hoover D, Spira T, Rinaldo C, Saah A, Phair J, Detels R, Parry P, Chang Y, Moore PS. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. New Eng. J. Med., 1996; 335:233-41. [Full Text] [PubMed]

Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, Levy JA, Gao SJ, Chang Y, Moore PS. Antibodies to butyrate inducible antigens of Kaposi's sarcoma-associated herpesvirus in HIV-1 infected patients. New Eng. J. Med., 1996; 334:1292-7. [Full Text] [PubMed]

Moore PS and Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma from persons with and without HIV infection. New Eng. J. Med., 1995; 332:1181-85. [Full Text] [PubMed]

Cesarman E, Chang Y, Moore PS, Said J, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences are detectable in AIDS-related body cavity based non-Hodgkin's lymphomas. New Eng J Med, 1995; 332:1186-91. [Full Text] [PubMed]

PS Moore, SJ Gao, G Dominguez, E Cesarman, O Lungu, DM Knowles, R Garber, PE Pellett, DJ McGeoch and Y Chang. Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma [published erratum appears in J. Virol 1996 70(12): 9083]. J. Virol 1996; 70: 549-58. [Full Text] [PubMed]

E Cesarman, PS Moore, PH Rao, G Inghirami, DM Knowles, and Y Chang In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences Blood, Oct 1995; 86: 2708 - 2714. [Full Text] [PubMed]

Jon Cohen. Controversy: Is KS Really Caused By New Herpesvirus? Science 1995; 268:1847-8. Moore PS, Chang Y. Kaposi sarcoma findings (or Hakuin Ekaku's koan: "Is that so?") Science 1995; 270:15 and Jon Cohen. Reports Bolster Viral Cause of KS. Science 1996; 273:573. [Full Text]

Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 265:1865-69. [Full Text] [PubMed]